Methylprednisolone is a synthetic steroid that suppresses acute and chronic inflammation. In addition, it potentiates vascular smooth muscle relaxation by beta adrenergic agonists, and may alter airway hyperactivity. A newer usage is for reduction of post-traumatic spinal cord edema
Acute spinal cord injury
Use with caution in patients with GI bleeding and diabetes melliutus.
Sodium and water retention
Hypoglycemic responses to insulin and oral hypoglycemic agents may be blunted.
Potassium-depleting agents may potentiate hypokalemia induced by corticosteroids
40,125, 500, 1000 mg vials
Variable, usually within 40-125 mg IV range, except for spinal cord injury where the initial dose is 30 mg/kg slow IV bolus followed by an infusion of 5.4 mg/kg/hr after the first hour.
Pregnancy Safety: Category C
Crosses the placenta and may cause fetal harm.