Doxepin Hydrochloride

Doxepin Hydrochloride


Trade name products which contain doxepin include: (Sinequan) (Adapin)
(Triadapin)


INDICATION

A tricyclic antidepressant medication used for the treatment of depression.
Occassionally used to treat itching.


SIDE EFFECTS

Drowsiness, dizziness, tremors, anxiety, confusion, weakness, headache,
increased heart rate, increased or decreased blood pressure, ringing in the
ears, blurred vision, tongue swelling, constipation, nausea, vomiting, dry
mouth, anorexia, paralytic ileus, rash, urine retention, and sweating. Rare
effects include: hallucinations, decreased sex drive, fainting, back pain,
itching, sore throat, involuntary movements of jaw, lips, and tongue,
nightmares, swollen breasts, and swollen testicles.


INTERACTIONS and PRECAUTIONS

1. Mao inhibitors (Nardil) can lead to anxiety, elevated body temperatures, and
seizures.
2. Methylphenidate may increase the antidepressant effects.
3. Cimetidine can increase the adverse effects of doxepin.
4. Barbiturates may decrease the effects of doxepin and lead to oversedation.
5. Use with anticoagulants (Coumadin) may increase anticoagulant effect.
6. Use with anticholinergics can increase anticholinergic effects.
7. Use with antihistamines can increase antihistamine effect.
8. Use with benzodiazepines can lead to oversedation.
9. Use with bupropion can increase risk of seizures.
10. Use with alcohol can increase intoxication--avoid.
11. Use with nicotine may decrease antidepressant effect.


USUAL DOSE

Adults:
Antidepressant: 25 mg three times a day
Antipruritic: 10 mg at bedtime
Children (under 12): dosage not established